<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2024 Workiva-->
<!--r:4001af36-60f7-4a78-a9b8-8cf66e65e82d,g:0e57d843-a75c-4a54-b496-f70ad1549f1e-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.tandemdiabetes.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="simple" xlink:href="tndm-20240331.xsd#CONDENSEDCONSOLIDATEDBALANCESHEETS"/>
  <link:calculationLink xlink:role="http://www.tandemdiabetes.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_cd37b95e-26b2-410a-8276-92044eb18015" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_25142923-fe32-4500-8ad6-c35817763173" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_cd37b95e-26b2-410a-8276-92044eb18015" xlink:to="loc_us-gaap_AccountsPayableCurrent_25142923-fe32-4500-8ad6-c35817763173" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_94f34cc5-5411-413d-9b57-cd08681911c5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_cd37b95e-26b2-410a-8276-92044eb18015" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_94f34cc5-5411-413d-9b57-cd08681911c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_1d63b94d-ab4b-416f-b0d6-7dff266efe21" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_cd37b95e-26b2-410a-8276-92044eb18015" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_1d63b94d-ab4b-416f-b0d6-7dff266efe21" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_feb6e10f-a82d-42a8-8153-ce9839403fb2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_cd37b95e-26b2-410a-8276-92044eb18015" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_feb6e10f-a82d-42a8-8153-ce9839403fb2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_8ce08a20-dbaf-48f1-9bf6-7808e9b010cb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_cd37b95e-26b2-410a-8276-92044eb18015" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_8ce08a20-dbaf-48f1-9bf6-7808e9b010cb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_935f9137-ae99-4bac-bf35-0083f9a5eeff" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_cd37b95e-26b2-410a-8276-92044eb18015" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_935f9137-ae99-4bac-bf35-0083f9a5eeff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_363a2dee-ed9a-414b-8da4-78540ae25862" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_2494d077-305f-4f07-b5f8-295d0f720e0e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_363a2dee-ed9a-414b-8da4-78540ae25862" xlink:to="loc_us-gaap_AssetsCurrent_2494d077-305f-4f07-b5f8-295d0f720e0e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_c7325929-5e26-4fc8-8ef6-49790a5a5175" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_363a2dee-ed9a-414b-8da4-78540ae25862" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_c7325929-5e26-4fc8-8ef6-49790a5a5175" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_01be65cd-a793-4d17-b601-049a4c5a9ad2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_363a2dee-ed9a-414b-8da4-78540ae25862" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_01be65cd-a793-4d17-b601-049a4c5a9ad2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_850b2390-9779-4974-ac7d-e2738a35c93e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_363a2dee-ed9a-414b-8da4-78540ae25862" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_850b2390-9779-4974-ac7d-e2738a35c93e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_3b3076cd-af66-4bea-ada9-377d50194a44" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtNoncurrent_34ee7b1f-073c-4b67-aeac-28cc867d01b8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConvertibleDebtNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_3b3076cd-af66-4bea-ada9-377d50194a44" xlink:to="loc_us-gaap_ConvertibleDebtNoncurrent_34ee7b1f-073c-4b67-aeac-28cc867d01b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_7cf34b32-a90b-4e54-9d25-5edc89304d3a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_3b3076cd-af66-4bea-ada9-377d50194a44" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_7cf34b32-a90b-4e54-9d25-5edc89304d3a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_19f68741-4d2f-4d22-a891-c6d1e8239929" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_3b3076cd-af66-4bea-ada9-377d50194a44" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_19f68741-4d2f-4d22-a891-c6d1e8239929" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_80ee9368-5659-4036-8c35-78afd44d24de" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_3b3076cd-af66-4bea-ada9-377d50194a44" xlink:to="loc_us-gaap_LiabilitiesCurrent_80ee9368-5659-4036-8c35-78afd44d24de" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_abf7cc43-ab5f-4190-a36d-bcb28e526737" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ContractWithCustomerLiabilityNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_3b3076cd-af66-4bea-ada9-377d50194a44" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_abf7cc43-ab5f-4190-a36d-bcb28e526737" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_f1394176-3161-4f3a-80db-fee0a5ada581" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_b9fbbe46-1885-4ebd-9242-a0894945acfe" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_f1394176-3161-4f3a-80db-fee0a5ada581" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_b9fbbe46-1885-4ebd-9242-a0894945acfe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestments_c849538c-12d3-4767-aa7a-d9ca6eef46b4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShortTermInvestments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_f1394176-3161-4f3a-80db-fee0a5ada581" xlink:to="loc_us-gaap_ShortTermInvestments_c849538c-12d3-4767-aa7a-d9ca6eef46b4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_3c0029b8-669d-4ba7-832d-190e27f30a04" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_f1394176-3161-4f3a-80db-fee0a5ada581" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_3c0029b8-669d-4ba7-832d-190e27f30a04" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_e907e049-bef4-4d78-b2bc-f49b6861c797" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_f1394176-3161-4f3a-80db-fee0a5ada581" xlink:to="loc_us-gaap_InventoryNet_e907e049-bef4-4d78-b2bc-f49b6861c797" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_34447ea9-46a0-4f86-a6a4-5e4c1db4d1b9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_f1394176-3161-4f3a-80db-fee0a5ada581" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_34447ea9-46a0-4f86-a6a4-5e4c1db4d1b9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_c48d75ed-7062-4e11-9160-0d4f2593db6a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_d53b2833-c1e8-43d2-b90a-6aca4881b836" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_c48d75ed-7062-4e11-9160-0d4f2593db6a" xlink:to="loc_us-gaap_CommonStockValue_d53b2833-c1e8-43d2-b90a-6aca4881b836" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_987718b5-7aa3-4fd6-8bd5-837b4fcc0173" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AdditionalPaidInCapitalCommonStock"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_c48d75ed-7062-4e11-9160-0d4f2593db6a" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_987718b5-7aa3-4fd6-8bd5-837b4fcc0173" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_321d4c06-3f23-4bb3-8de0-572218641222" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_c48d75ed-7062-4e11-9160-0d4f2593db6a" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_321d4c06-3f23-4bb3-8de0-572218641222" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_624d0cf7-7e23-48c8-b1e5-061100a0f739" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_c48d75ed-7062-4e11-9160-0d4f2593db6a" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_624d0cf7-7e23-48c8-b1e5-061100a0f739" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_c9bc6148-d36d-4efd-be43-976102f73f7f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_04296084-6ac4-4283-b4d7-e02442ee95e1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_c9bc6148-d36d-4efd-be43-976102f73f7f" xlink:to="loc_us-gaap_Liabilities_04296084-6ac4-4283-b4d7-e02442ee95e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_3baf2f93-ece6-43e5-af7c-39fe05d275f7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_c9bc6148-d36d-4efd-be43-976102f73f7f" xlink:to="loc_us-gaap_CommitmentsAndContingencies_3baf2f93-ece6-43e5-af7c-39fe05d275f7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_fe201f4c-4dd9-482c-a5aa-fb5b38ccc6b1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_c9bc6148-d36d-4efd-be43-976102f73f7f" xlink:to="loc_us-gaap_StockholdersEquity_fe201f4c-4dd9-482c-a5aa-fb5b38ccc6b1" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.tandemdiabetes.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVEINCOMELOSSUnaudited" xlink:type="simple" xlink:href="tndm-20240331.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVEINCOMELOSSUnaudited"/>
  <link:calculationLink xlink:role="http://www.tandemdiabetes.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVEINCOMELOSSUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_36dc390f-cd52-4b72-9f03-dc7b6e07657f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff_83c5c98d-7c65-4475-b922-b732db4c2169" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_36dc390f-cd52-4b72-9f03-dc7b6e07657f" xlink:to="loc_us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff_83c5c98d-7c65-4475-b922-b732db4c2169" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_6511be21-0005-4a84-a4d7-9d687e438ebb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_36dc390f-cd52-4b72-9f03-dc7b6e07657f" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_6511be21-0005-4a84-a4d7-9d687e438ebb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_1971aaef-cd8a-4e04-bc91-4217f002eb9b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_36dc390f-cd52-4b72-9f03-dc7b6e07657f" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_1971aaef-cd8a-4e04-bc91-4217f002eb9b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_2a2bee47-c255-48cd-8a61-c6dc08f77ee3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_d9ac2a20-e4f1-4b59-91bb-68293b261592" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_2a2bee47-c255-48cd-8a61-c6dc08f77ee3" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_d9ac2a20-e4f1-4b59-91bb-68293b261592" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_6474013f-51ce-49cf-a7a3-a4b645371298" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_2a2bee47-c255-48cd-8a61-c6dc08f77ee3" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_6474013f-51ce-49cf-a7a3-a4b645371298" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_8db75cbe-69d6-4326-aef0-0051071311f0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_4da1fc6d-9c15-4cf5-bf28-6a3c60f50849" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_8db75cbe-69d6-4326-aef0-0051071311f0" xlink:to="loc_us-gaap_GrossProfit_4da1fc6d-9c15-4cf5-bf28-6a3c60f50849" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_082205a1-f951-467d-b706-337ec2d6ffad" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_8db75cbe-69d6-4326-aef0-0051071311f0" xlink:to="loc_us-gaap_OperatingExpenses_082205a1-f951-467d-b706-337ec2d6ffad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_03b9e227-00de-4890-8255-fa5b44c25769" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_6d353571-a25d-4c0a-b093-0fdce1403665" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_03b9e227-00de-4890-8255-fa5b44c25769" xlink:to="loc_us-gaap_NetIncomeLoss_6d353571-a25d-4c0a-b093-0fdce1403665" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_0be900ef-86c0-4e75-aeb6-7320e86f6f15" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_03b9e227-00de-4890-8255-fa5b44c25769" xlink:to="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_0be900ef-86c0-4e75-aeb6-7320e86f6f15" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_22511c83-258d-44f2-9fde-3607c6a1247e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_03b9e227-00de-4890-8255-fa5b44c25769" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_22511c83-258d-44f2-9fde-3607c6a1247e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_6484dacc-88d2-46ce-a660-166c479485a6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_61547961-a0f9-4227-be5a-c9bde030bce5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_6484dacc-88d2-46ce-a660-166c479485a6" xlink:to="loc_us-gaap_OperatingIncomeLoss_61547961-a0f9-4227-be5a-c9bde030bce5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_7a5c46f7-0cd9-4525-a5fb-f0dca8817991" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_6484dacc-88d2-46ce-a660-166c479485a6" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_7a5c46f7-0cd9-4525-a5fb-f0dca8817991" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_71e0c689-f82c-41c4-8be3-e6099ce85b0d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndOtherIncome_c0b2b273-87a9-47c1-b9c7-d5da7c1cb58c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestAndOtherIncome"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpense_71e0c689-f82c-41c4-8be3-e6099ce85b0d" xlink:to="loc_us-gaap_InterestAndOtherIncome_c0b2b273-87a9-47c1-b9c7-d5da7c1cb58c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseOther_cee9df6b-ca98-452e-98fb-b09c3a2a8bf9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestExpenseOther"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpense_71e0c689-f82c-41c4-8be3-e6099ce85b0d" xlink:to="loc_us-gaap_InterestExpenseOther_cee9df6b-ca98-452e-98fb-b09c3a2a8bf9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_f1849aaf-b0ee-41c1-8dda-2cbd446804a0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpense_71e0c689-f82c-41c4-8be3-e6099ce85b0d" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_f1849aaf-b0ee-41c1-8dda-2cbd446804a0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_eae1afaa-cbed-4bb7-b1fb-6363b44193d7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_83e464f0-a101-4477-96e5-e0d56530eb65" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_eae1afaa-cbed-4bb7-b1fb-6363b44193d7" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_83e464f0-a101-4477-96e5-e0d56530eb65" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_c9bda221-1913-414b-8cd2-26a5e9b0111c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_eae1afaa-cbed-4bb7-b1fb-6363b44193d7" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_c9bda221-1913-414b-8cd2-26a5e9b0111c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.tandemdiabetes.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSUnaudited" xlink:type="simple" xlink:href="tndm-20240331.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSUnaudited"/>
  <link:calculationLink xlink:role="http://www.tandemdiabetes.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_5154fbea-983f-4a0a-838a-c5e866edc8a0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_3f1d4bb0-a3f4-4570-ace6-37cf4740a8e0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_5154fbea-983f-4a0a-838a-c5e866edc8a0" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_3f1d4bb0-a3f4-4570-ace6-37cf4740a8e0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForDoubtfulAccounts_6e56de80-d409-4aa6-9c08-9e2e1a9e3d24" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProvisionForDoubtfulAccounts"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_5154fbea-983f-4a0a-838a-c5e866edc8a0" xlink:to="loc_us-gaap_ProvisionForDoubtfulAccounts_6e56de80-d409-4aa6-9c08-9e2e1a9e3d24" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInEmployeeRelatedLiabilities_886086e0-3914-412c-989f-58608838c4a8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInEmployeeRelatedLiabilities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_5154fbea-983f-4a0a-838a-c5e866edc8a0" xlink:to="loc_us-gaap_IncreaseDecreaseInEmployeeRelatedLiabilities_886086e0-3914-412c-989f-58608838c4a8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_2c43e727-6e67-47c1-8c7b-495d3d42f544" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_5154fbea-983f-4a0a-838a-c5e866edc8a0" xlink:to="loc_us-gaap_ProfitLoss_2c43e727-6e67-47c1-8c7b-495d3d42f544" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_3af87c52-bcdc-42c0-b270-82874fc72882" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_5154fbea-983f-4a0a-838a-c5e866edc8a0" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_3af87c52-bcdc-42c0-b270-82874fc72882" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_2d41cbf4-4408-436b-a418-d86200853572" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AmortizationOfFinancingCosts"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_5154fbea-983f-4a0a-838a-c5e866edc8a0" xlink:to="loc_us-gaap_AmortizationOfFinancingCosts_2d41cbf4-4408-436b-a418-d86200853572" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff_96363bd3-26ba-4486-8110-a15c88d4a900" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_5154fbea-983f-4a0a-838a-c5e866edc8a0" xlink:to="loc_us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff_96363bd3-26ba-4486-8110-a15c88d4a900" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_828cee78-d606-4940-8ae0-720017afe2f7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_5154fbea-983f-4a0a-838a-c5e866edc8a0" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_828cee78-d606-4940-8ae0-720017afe2f7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_1eae20e1-642a-4d79-ab32-f12191852e87" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_5154fbea-983f-4a0a-838a-c5e866edc8a0" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_1eae20e1-642a-4d79-ab32-f12191852e87" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_d9327f46-6b86-4a78-9579-b9e4d9875aad" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_5154fbea-983f-4a0a-838a-c5e866edc8a0" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_d9327f46-6b86-4a78-9579-b9e4d9875aad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_7e3da768-c950-4568-a82a-5dc920217b79" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_5154fbea-983f-4a0a-838a-c5e866edc8a0" xlink:to="loc_us-gaap_ShareBasedCompensation_7e3da768-c950-4568-a82a-5dc920217b79" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_d68ba820-f6c4-4af1-9cc0-ec226fb9e9af" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentAssets"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_5154fbea-983f-4a0a-838a-c5e866edc8a0" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_d68ba820-f6c4-4af1-9cc0-ec226fb9e9af" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeNetAmortizationOfDiscountAndPremium_446ab2db-4c26-40c3-8332-1cf2a747c7b2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InvestmentIncomeNetAmortizationOfDiscountAndPremium"/>
    <link:calculationArc order="13" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_5154fbea-983f-4a0a-838a-c5e866edc8a0" xlink:to="loc_us-gaap_InvestmentIncomeNetAmortizationOfDiscountAndPremium_446ab2db-4c26-40c3-8332-1cf2a747c7b2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_d91565c6-9db4-413f-8f69-1b77f4447354" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="14" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_5154fbea-983f-4a0a-838a-c5e866edc8a0" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_d91565c6-9db4-413f-8f69-1b77f4447354" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_70ec0285-082a-47d3-baa1-376790aada56" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInOperatingLeaseLiability"/>
    <link:calculationArc order="15" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_5154fbea-983f-4a0a-838a-c5e866edc8a0" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_70ec0285-082a-47d3-baa1-376790aada56" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_d59ebefb-6777-4146-88c9-28a715872f3d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/>
    <link:calculationArc order="16" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_5154fbea-983f-4a0a-838a-c5e866edc8a0" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_d59ebefb-6777-4146-88c9-28a715872f3d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities_16e24b90-1338-4745-af68-c3a363fac717" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities"/>
    <link:calculationArc order="17" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_5154fbea-983f-4a0a-838a-c5e866edc8a0" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities_16e24b90-1338-4745-af68-c3a363fac717" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherOperatingActivitiesCashFlowStatement_7d33e313-01af-4794-a8a4-bde367f11da6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherOperatingActivitiesCashFlowStatement"/>
    <link:calculationArc order="18" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_5154fbea-983f-4a0a-838a-c5e866edc8a0" xlink:to="loc_us-gaap_OtherOperatingActivitiesCashFlowStatement_7d33e313-01af-4794-a8a4-bde367f11da6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_20261bf6-5034-47a4-ba5d-a783cb9638e3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireShortTermInvestments_7e542ff7-57f6-48b0-8a01-06ce519c6670" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsToAcquireShortTermInvestments"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_20261bf6-5034-47a4-ba5d-a783cb9638e3" xlink:to="loc_us-gaap_PaymentsToAcquireShortTermInvestments_7e542ff7-57f6-48b0-8a01-06ce519c6670" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments_2e5013b7-6768-4ec7-b0e3-eb736e1c5839" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_20261bf6-5034-47a4-ba5d-a783cb9638e3" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments_2e5013b7-6768-4ec7-b0e3-eb736e1c5839" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_tndm_PaymentsToAcquireIntangibleAssetsAndStrategicInvestments_706b8454-5e0f-4011-9cf4-917dfdd74559" xlink:href="tndm-20240331.xsd#tndm_PaymentsToAcquireIntangibleAssetsAndStrategicInvestments"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_20261bf6-5034-47a4-ba5d-a783cb9638e3" xlink:to="loc_tndm_PaymentsToAcquireIntangibleAssetsAndStrategicInvestments_706b8454-5e0f-4011-9cf4-917dfdd74559" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireInProcessResearchAndDevelopment_9661494e-5905-4875-9d41-4ef255490d47" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsToAcquireInProcessResearchAndDevelopment"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_20261bf6-5034-47a4-ba5d-a783cb9638e3" xlink:to="loc_us-gaap_PaymentsToAcquireInProcessResearchAndDevelopment_9661494e-5905-4875-9d41-4ef255490d47" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_b6a332fb-4afe-4f11-ae85-c34769b4f82f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_20261bf6-5034-47a4-ba5d-a783cb9638e3" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_b6a332fb-4afe-4f11-ae85-c34769b4f82f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_9482d93d-3504-4a3e-b2a5-be8c2783638d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_tndm_PaymentsForCappedCallTransactions_a0a0fa31-8339-4730-9c53-3e7ad6b44ebb" xlink:href="tndm-20240331.xsd#tndm_PaymentsForCappedCallTransactions"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_9482d93d-3504-4a3e-b2a5-be8c2783638d" xlink:to="loc_tndm_PaymentsForCappedCallTransactions_a0a0fa31-8339-4730-9c53-3e7ad6b44ebb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfConvertibleDebt_cea4063f-ffef-4232-8e5b-3bf8864e9b8f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RepaymentsOfConvertibleDebt"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_9482d93d-3504-4a3e-b2a5-be8c2783638d" xlink:to="loc_us-gaap_RepaymentsOfConvertibleDebt_cea4063f-ffef-4232-8e5b-3bf8864e9b8f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromConvertibleDebt_cf746b4c-5ab8-4262-8902-a492316421dd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromConvertibleDebt"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_9482d93d-3504-4a3e-b2a5-be8c2783638d" xlink:to="loc_us-gaap_ProceedsFromConvertibleDebt_cf746b4c-5ab8-4262-8902-a492316421dd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_722572f5-1786-4c49-98b7-af3d5dfe79ec" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_9482d93d-3504-4a3e-b2a5-be8c2783638d" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_722572f5-1786-4c49-98b7-af3d5dfe79ec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_7219c469-b86c-452a-a473-74e46c5e71ce" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromPaymentsForOtherFinancingActivities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_9482d93d-3504-4a3e-b2a5-be8c2783638d" xlink:to="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_7219c469-b86c-452a-a473-74e46c5e71ce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_9eddde64-5938-45e8-aeed-30f16822c570" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_9482d93d-3504-4a3e-b2a5-be8c2783638d" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_9eddde64-5938-45e8-aeed-30f16822c570" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_c6daab92-f6e6-4b08-b5ae-34b4b4919dad" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2c061cb8-ad5e-45cc-9aa8-e819b055f31b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_c6daab92-f6e6-4b08-b5ae-34b4b4919dad" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2c061cb8-ad5e-45cc-9aa8-e819b055f31b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_bd0878a5-0589-4633-a97f-065c90c6f299" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_c6daab92-f6e6-4b08-b5ae-34b4b4919dad" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_bd0878a5-0589-4633-a97f-065c90c6f299" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_df8260fb-a6b0-4987-a7a5-ebfc028d4d34" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_c6daab92-f6e6-4b08-b5ae-34b4b4919dad" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_df8260fb-a6b0-4987-a7a5-ebfc028d4d34" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_118cbafa-2d8e-465f-bf7a-6a4a1f35e129" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_c6daab92-f6e6-4b08-b5ae-34b4b4919dad" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_118cbafa-2d8e-465f-bf7a-6a4a1f35e129" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.tandemdiabetes.com/role/SummaryofSignificantAccountingPoliciesTotalEstimatedSalesRebatesDetails" xlink:type="simple" xlink:href="tndm-20240331.xsd#SummaryofSignificantAccountingPoliciesTotalEstimatedSalesRebatesDetails"/>
  <link:calculationLink xlink:role="http://www.tandemdiabetes.com/role/SummaryofSignificantAccountingPoliciesTotalEstimatedSalesRebatesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_tndm_EstimatedSalesRebates_15d3b56b-c92e-4e6a-aa1b-9c96401cbfec" xlink:href="tndm-20240331.xsd#tndm_EstimatedSalesRebates"/>
    <link:loc xlink:type="locator" xlink:label="loc_tndm_EstimatedSalesRebatesCurrent_c5f37233-b69c-4c57-aff9-d17637c8fd5c" xlink:href="tndm-20240331.xsd#tndm_EstimatedSalesRebatesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_tndm_EstimatedSalesRebates_15d3b56b-c92e-4e6a-aa1b-9c96401cbfec" xlink:to="loc_tndm_EstimatedSalesRebatesCurrent_c5f37233-b69c-4c57-aff9-d17637c8fd5c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_tndm_EstimatedSalesRebatesNoncurrent_78d8b008-3c80-4b10-9902-c5bfdfc8cb68" xlink:href="tndm-20240331.xsd#tndm_EstimatedSalesRebatesNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_tndm_EstimatedSalesRebates_15d3b56b-c92e-4e6a-aa1b-9c96401cbfec" xlink:to="loc_tndm_EstimatedSalesRebatesNoncurrent_78d8b008-3c80-4b10-9902-c5bfdfc8cb68" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.tandemdiabetes.com/role/SummaryofSignificantAccountingPoliciesReconciliationofChangeinEstimatedWarrantyLiabilitiesDetails" xlink:type="simple" xlink:href="tndm-20240331.xsd#SummaryofSignificantAccountingPoliciesReconciliationofChangeinEstimatedWarrantyLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.tandemdiabetes.com/role/SummaryofSignificantAccountingPoliciesReconciliationofChangeinEstimatedWarrantyLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductWarrantyAccrual_0cbb843d-2481-41b5-ae89-151ebd5402e3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProductWarrantyAccrual"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductWarrantyAccrualNoncurrent_24c61820-4d6f-4f76-945b-c067f598860c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProductWarrantyAccrualNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ProductWarrantyAccrual_0cbb843d-2481-41b5-ae89-151ebd5402e3" xlink:to="loc_us-gaap_ProductWarrantyAccrualNoncurrent_24c61820-4d6f-4f76-945b-c067f598860c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductWarrantyAccrualClassifiedCurrent_bb02792d-b5fe-4c4d-a982-3ca4a0fe5fc3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProductWarrantyAccrualClassifiedCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ProductWarrantyAccrual_0cbb843d-2481-41b5-ae89-151ebd5402e3" xlink:to="loc_us-gaap_ProductWarrantyAccrualClassifiedCurrent_bb02792d-b5fe-4c4d-a982-3ca4a0fe5fc3" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.tandemdiabetes.com/role/ShortTermInvestmentsEstimatedFairValueofShortTermInvestmentsDetails" xlink:type="simple" xlink:href="tndm-20240331.xsd#ShortTermInvestmentsEstimatedFairValueofShortTermInvestmentsDetails"/>
  <link:calculationLink xlink:role="http://www.tandemdiabetes.com/role/ShortTermInvestmentsEstimatedFairValueofShortTermInvestmentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_ae3eceaf-b5da-4447-9693-983b6762a084" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_48ea959e-b193-4f20-b7e5-874d2764b0b1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_ae3eceaf-b5da-4447-9693-983b6762a084" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_48ea959e-b193-4f20-b7e5-874d2764b0b1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_a3736be4-0520-48d8-a100-2933e767798c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_ae3eceaf-b5da-4447-9693-983b6762a084" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_a3736be4-0520-48d8-a100-2933e767798c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_4f29b7e9-8e47-40be-ae10-69a78ed09780" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_ae3eceaf-b5da-4447-9693-983b6762a084" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_4f29b7e9-8e47-40be-ae10-69a78ed09780" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.tandemdiabetes.com/role/ShortTermInvestmentsContractualMaturitiesofAvailableForSaleDebtSecuritiesDetails" xlink:type="simple" xlink:href="tndm-20240331.xsd#ShortTermInvestmentsContractualMaturitiesofAvailableForSaleDebtSecuritiesDetails"/>
  <link:calculationLink xlink:role="http://www.tandemdiabetes.com/role/ShortTermInvestmentsContractualMaturitiesofAvailableForSaleDebtSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesSingleMaturityDate_fbd7a58d-b71a-4718-a7fc-4bd61b4bd0cf" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesSingleMaturityDate"/>
    <link:loc xlink:type="locator" xlink:label="loc_tndm_DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateAfterYearOneThroughTwo_0a1e4ba3-7edc-4cf6-b1ea-2d5ca2040d57" xlink:href="tndm-20240331.xsd#tndm_DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateAfterYearOneThroughTwo"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesSingleMaturityDate_fbd7a58d-b71a-4718-a7fc-4bd61b4bd0cf" xlink:to="loc_tndm_DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateAfterYearOneThroughTwo_0a1e4ba3-7edc-4cf6-b1ea-2d5ca2040d57" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_b974db4d-3997-4693-b92b-8a8a55b9ac73" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesSingleMaturityDate_fbd7a58d-b71a-4718-a7fc-4bd61b4bd0cf" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_b974db4d-3997-4693-b92b-8a8a55b9ac73" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_tndm_DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateAfterYearTwoThroughThree_01e7a6ed-03ce-4100-ae44-10a4d833500a" xlink:href="tndm-20240331.xsd#tndm_DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateAfterYearTwoThroughThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesSingleMaturityDate_fbd7a58d-b71a-4718-a7fc-4bd61b4bd0cf" xlink:to="loc_tndm_DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateAfterYearTwoThroughThree_01e7a6ed-03ce-4100-ae44-10a4d833500a" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.tandemdiabetes.com/role/CompositionofCertainFinancialStatementItemsAccountsReceivableDetails" xlink:type="simple" xlink:href="tndm-20240331.xsd#CompositionofCertainFinancialStatementItemsAccountsReceivableDetails"/>
  <link:calculationLink xlink:role="http://www.tandemdiabetes.com/role/CompositionofCertainFinancialStatementItemsAccountsReceivableDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNet_e6654de8-3c75-40c1-b218-5e091107cc18" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccountsReceivableNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableGross_71072985-17b7-4176-b7df-bb9ae5c71a4f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccountsReceivableGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsReceivableNet_e6654de8-3c75-40c1-b218-5e091107cc18" xlink:to="loc_us-gaap_AccountsReceivableGross_71072985-17b7-4176-b7df-bb9ae5c71a4f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivable_336a4da1-61a6-4e25-8a79-746a33e6b728" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivable"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsReceivableNet_e6654de8-3c75-40c1-b218-5e091107cc18" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivable_336a4da1-61a6-4e25-8a79-746a33e6b728" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.tandemdiabetes.com/role/CompositionofCertainFinancialStatementItemsInventoryDetails" xlink:type="simple" xlink:href="tndm-20240331.xsd#CompositionofCertainFinancialStatementItemsInventoryDetails"/>
  <link:calculationLink xlink:role="http://www.tandemdiabetes.com/role/CompositionofCertainFinancialStatementItemsInventoryDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_6fceaaa5-2dce-4e20-92e1-b9f11e697256" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcess_c71bfb1c-3487-4e3c-887f-7f11d665bc98" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryWorkInProcess"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_6fceaaa5-2dce-4e20-92e1-b9f11e697256" xlink:to="loc_us-gaap_InventoryWorkInProcess_c71bfb1c-3487-4e3c-887f-7f11d665bc98" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoods_587a91fb-cc5c-438f-9952-79f15e374f9d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryFinishedGoods"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_6fceaaa5-2dce-4e20-92e1-b9f11e697256" xlink:to="loc_us-gaap_InventoryFinishedGoods_587a91fb-cc5c-438f-9952-79f15e374f9d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterials_8928a6d2-f821-4a1e-a1a1-d503795557e7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryRawMaterials"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_6fceaaa5-2dce-4e20-92e1-b9f11e697256" xlink:to="loc_us-gaap_InventoryRawMaterials_8928a6d2-f821-4a1e-a1a1-d503795557e7" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.tandemdiabetes.com/role/FairValueMeasurementsFinancialAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails" xlink:type="simple" xlink:href="tndm-20240331.xsd#FairValueMeasurementsFinancialAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"/>
  <link:calculationLink xlink:role="http://www.tandemdiabetes.com/role/FairValueMeasurementsFinancialAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_13031b74-3bfd-44ea-95c1-b644c7c60ec4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_a05dafce-9de2-4d4f-b359-b2dd41d871b3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_13031b74-3bfd-44ea-95c1-b644c7c60ec4" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_a05dafce-9de2-4d4f-b359-b2dd41d871b3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_f218d501-c2e0-40bf-bb44-95df3e003423" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_13031b74-3bfd-44ea-95c1-b644c7c60ec4" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_f218d501-c2e0-40bf-bb44-95df3e003423" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.tandemdiabetes.com/role/LeasesLeaseCostDetails" xlink:type="simple" xlink:href="tndm-20240331.xsd#LeasesLeaseCostDetails"/>
  <link:calculationLink xlink:role="http://www.tandemdiabetes.com/role/LeasesLeaseCostDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseCost_3b396590-d0e1-4710-b980-add4086e95b3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LeaseCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermLeaseCost_09187d91-60bc-4f76-9c5b-8157bdb20ae2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShortTermLeaseCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_3b396590-d0e1-4710-b980-add4086e95b3" xlink:to="loc_us-gaap_ShortTermLeaseCost_09187d91-60bc-4f76-9c5b-8157bdb20ae2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseCost_38e213a8-0942-4e00-a5b4-a08a1fde4c90" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLeaseCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_3b396590-d0e1-4710-b980-add4086e95b3" xlink:to="loc_us-gaap_OperatingLeaseCost_38e213a8-0942-4e00-a5b4-a08a1fde4c90" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.tandemdiabetes.com/role/LeasesFutureMinimumPaymentsUnderNoncancellableOperatingLeasesDetails" xlink:type="simple" xlink:href="tndm-20240331.xsd#LeasesFutureMinimumPaymentsUnderNoncancellableOperatingLeasesDetails"/>
  <link:calculationLink xlink:role="http://www.tandemdiabetes.com/role/LeasesFutureMinimumPaymentsUnderNoncancellableOperatingLeasesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_e804479e-766e-4b2a-be13-208788250cd3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_021fcea5-9a0a-4114-a4c8-5d91262900c7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeaseLiability_e804479e-766e-4b2a-be13-208788250cd3" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_021fcea5-9a0a-4114-a4c8-5d91262900c7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_caa6e21c-561d-4be7-b184-cc9c6ca6b151" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeaseLiability_e804479e-766e-4b2a-be13-208788250cd3" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_caa6e21c-561d-4be7-b184-cc9c6ca6b151" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_9f61dbda-b5b8-441b-9e1d-fa3c3b1bd268" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_f8488cbe-cdf7-4f6d-b1a0-053189b83f27" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_9f61dbda-b5b8-441b-9e1d-fa3c3b1bd268" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_f8488cbe-cdf7-4f6d-b1a0-053189b83f27" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_tndm_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour_29931f70-eabe-460e-a148-34adb6490035" xlink:href="tndm-20240331.xsd#tndm_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_9f61dbda-b5b8-441b-9e1d-fa3c3b1bd268" xlink:to="loc_tndm_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour_29931f70-eabe-460e-a148-34adb6490035" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_95badd58-edd5-4cea-8541-884f568bb1df" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_9f61dbda-b5b8-441b-9e1d-fa3c3b1bd268" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_95badd58-edd5-4cea-8541-884f568bb1df" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_d4948ef3-3ff8-40e7-a211-ef4dd1be04c0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_9f61dbda-b5b8-441b-9e1d-fa3c3b1bd268" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_d4948ef3-3ff8-40e7-a211-ef4dd1be04c0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_7b597d9f-f0cb-49f1-832f-ed08fc5c658b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_9f61dbda-b5b8-441b-9e1d-fa3c3b1bd268" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_7b597d9f-f0cb-49f1-832f-ed08fc5c658b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_8ce9ae14-2aa9-4c5a-b7d3-36ace1d05619" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_9f61dbda-b5b8-441b-9e1d-fa3c3b1bd268" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_8ce9ae14-2aa9-4c5a-b7d3-36ace1d05619" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.tandemdiabetes.com/role/LeasesFutureMinimumPaymentsUnderNoncancellableOperatingLeasesDetails_1" xlink:type="simple" xlink:href="tndm-20240331.xsd#LeasesFutureMinimumPaymentsUnderNoncancellableOperatingLeasesDetails_1"/>
  <link:calculationLink xlink:role="http://www.tandemdiabetes.com/role/LeasesFutureMinimumPaymentsUnderNoncancellableOperatingLeasesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_082f0233-6122-4670-854e-92e7b220a903" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_9496db6f-c4bf-4388-bc97-64253ea08201" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_082f0233-6122-4670-854e-92e7b220a903" xlink:to="loc_us-gaap_OperatingLeaseLiability_9496db6f-c4bf-4388-bc97-64253ea08201" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_685b0ebf-d1d5-4314-ae0d-f1974045c523" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_082f0233-6122-4670-854e-92e7b220a903" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_685b0ebf-d1d5-4314-ae0d-f1974045c523" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.tandemdiabetes.com/role/DebtComponentsofConvertibleNoteDetails" xlink:type="simple" xlink:href="tndm-20240331.xsd#DebtComponentsofConvertibleNoteDetails"/>
  <link:calculationLink xlink:role="http://www.tandemdiabetes.com/role/DebtComponentsofConvertibleNoteDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_17f7bfc6-a720-4186-b76a-7f72ae152f08" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongTermDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_273a3203-136d-449c-8373-0c38ffc01111" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_17f7bfc6-a720-4186-b76a-7f72ae152f08" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_273a3203-136d-449c-8373-0c38ffc01111" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_9a8ddeb7-f8cb-46de-8587-4f4d07237987" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredFinanceCostsNet"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_17f7bfc6-a720-4186-b76a-7f72ae152f08" xlink:to="loc_us-gaap_DeferredFinanceCostsNet_9a8ddeb7-f8cb-46de-8587-4f4d07237987" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.tandemdiabetes.com/role/DebtInterestExpenseRecognizedDetails" xlink:type="simple" xlink:href="tndm-20240331.xsd#DebtInterestExpenseRecognizedDetails"/>
  <link:calculationLink xlink:role="http://www.tandemdiabetes.com/role/DebtInterestExpenseRecognizedDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseDebt_fd214372-02d4-4438-8074-c918959fed44" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestExpenseDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_739620ef-39f8-428d-ade7-a188e8cf1b50" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AmortizationOfFinancingCosts"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpenseDebt_fd214372-02d4-4438-8074-c918959fed44" xlink:to="loc_us-gaap_AmortizationOfFinancingCosts_739620ef-39f8-428d-ade7-a188e8cf1b50" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseDebtExcludingAmortization_aa552022-5c77-4413-89e7-c9d5bfde00c1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestExpenseDebtExcludingAmortization"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpenseDebt_fd214372-02d4-4438-8074-c918959fed44" xlink:to="loc_us-gaap_InterestExpenseDebtExcludingAmortization_aa552022-5c77-4413-89e7-c9d5bfde00c1" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
